Abstract
BackgroundAnxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients.MethodThe data were collected from 60 AD patients, 38 UAD patients, and 60 matched healthy controls. The ALFF and seed-based FC were examined. Pearson correlations were computed between ALFF/FC and clinical measures.ResultsIn Comparison with the UAD group, the ALFF value of the right orbital part of middle frontal gyrus (RO-MFG) decreased in AD group. Specifically, the ALFF values of the RO-MFG were negatively correlated with retardation factor scores in AD group (r = -0.376, p = 0.003).ConclusionsAD patients exhibited disturbed intrinsic brain function compared with UAD patients. The decreased activity of the RO-MFG is indicative of the alterations involved in the neural basis of AD.
Highlights
Major depressive disorder (MDD), which ranks second among the leading cause of disability in the world [1], has both high incidence and clinical severity [2]
There was no significant difference in the duration of illness between anxious depression (AD) and unanxious depression (UAD) group
Our results showed that patients with AD had decreased amplitude of low-frequency fluctuation (ALFF) values in right orbital part of middle frontal gyrus (RO-MFG) when compared with UADs
Summary
Major depressive disorder (MDD), which ranks second among the leading cause of disability in the world [1], has both high incidence and clinical severity [2]. In addition to having a lower response to antidepressants and more drug side effects, patients with AD usually take twice as long to recover from episode [9,10,11,12,13]. These combined downsides motivated us to further uncover the neural mechanisms behind AD. Anxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients
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