Abstract

ObjectiveTo test the hypothesis that wide area detector face transplant surgical planning CT angiograms with simulated lower radiation dose and iterative reconstruction (AIDR3D) are comparable in image quality to those with standard tube current and filtered back projection (FBP) reconstruction.Materials and MethodsThe sinograms from 320-detector row CT angiography of four clinical candidates for face transplantation were processed utilizing standard FBP, FBP with simulated 75, 62, and 50% tube current, and AIDR3D with corresponding dose reduction. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were measured at muscle, fat, artery, and vein. Image quality for each reconstruction strategy was assessed by two independent readers using a 4-point scale.ResultsCompared to FBP, the median SNR and CNR for AIDR3D images were higher at all sites for all 4 different tube currents. The AIDR3D with simulated 50% tube current achieved comparable SNR and CNR to FBP with standard dose (median muscle SNR: 5.77 vs. 6.23; fat SNR: 6.40 vs. 5.75; artery SNR: 43.8 vs. 45.0; vein SNR: 54.9 vs. 55.7; artery CNR: 38.1 vs. 38.6; vein CNR: 49.0 vs. 48.7; all p-values >0.19). The interobserver agreement in the image quality score was good (weighted κ = 0.7). The overall score and the scores for smaller arteries were significantly lower when FBP with 50% dose reduction was used. The AIDR3D reconstruction images with 4 different simulated doses achieved a mean score ranging from 3.68 to 3.82 that were comparable to the scores from images reconstructed using FBP with original dose (3.68–3.77).ConclusionsSimulated radiation dose reduction applied to clinical CT angiography for face transplant planning suggests that AIDR3D allows for a 50% reduction in radiation dose, as compared to FBP, while preserving image quality.

Highlights

  • Facial allograft transplantation restores form and function in patients with severe deformities [1] and is rapidly gaining acceptance for complex craniofacial reconstruction

  • Compared to filtered back projection (FBP), the median Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) for AIDR3D images were higher at all sites for all 4 different tube currents

  • The AIDR3D reconstruction images with 4 different simulated doses achieved a mean score ranging from 3.68 to 3.82 that were comparable to the scores from images reconstructed using FBP with original dose (3.68–3.77)

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Summary

Introduction

Facial allograft transplantation restores form and function in patients with severe deformities [1] and is rapidly gaining acceptance for complex craniofacial reconstruction. Vascular anastomosis is critical to technical success, and pre-operative vascular mapping [2] plays a large role for a safer procedure [3]. Both Computed Tomography (CT) and magnetic resonance methods [4,5] have been studied for surgical planning [6]. There is a single report of radiation exposure for face transplant CTA [2]. Given the rapid growth of face transplant programs and multiple CT studies that patients will undergo as screening and follow-up, consideration of radiation doses for comprehensive CT examination is prudent

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