Abstract
The effects of gentamicin, tetracycline, and a combination of neomycin and sulfathiazole on bone marrow proliferation were studied in mice. Spleen colony and granulocyte production by syngeneic bone marrow transplanted to lethally irradiated mice were significantly decreased when antibiotics were administered to the marrow recipients. Antibiotic administration to marrow donors had no effect on marrow proliferation before or after transplantation. It is likely that the observed effects were the result of alterations in the gastrointestinal flora of the marrow transplant recipients.
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