Abstract
Reports suggest that antituberculosis drugs are malabsorbed in patients with advanced HIV disease. To evaluate the pharmacokinetics of antituberculosis agents in HIV-seropositive patients at different stages of disease. Parallel study. Two hospital outpatient clinics. 12 healthy volunteers, 12 patients with asymptomatic HIV disease, 12 patients with symptomatic HIV disease, and 12 patients with symptomatic HIV disease and diarrhea. Drug plasma concentrations were measured over 24 hours on day 4 of concurrent therapy. Oral isoniazid (300 mg/d), rifampin (600 mg/d), pyrazinamide (1000 mg/d), and ethambutol (1000 mg/d). Reduced total drug exposure to rifampin and pyrazinamide was associated with D-xylose malabsorption in persons with HIV infection or AIDS. Peak drug exposure to isoniazid was lower in patients with diarrhea. Reduced total drug exposure may be related to malabsorption in persons with HIV infection or AIDS.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
