Abstract
The purpose of the study is to investigate whether reduced peak GH response to arginine-levodopa test is associated with hyperuricemia in obese children and adolescents. The study population consisted of a total sample of 78 obese and 30 normal-weight children and adolescents without known hypopituitarism. All participants underwent clinical examination and GH stimulation testing. IGF-1, lipid profile and other metabolic markers were assessed. The obese subjects were then divided into two groups according to the serum levels of uric acid. Results show that obese subjects had significantly lower peak GH, lower IGF-1 and similar height SDS than those in the control group. Children with hyperuricemia had significantly lower peak stimulated GH compared with non-hyperuricemia obese subjects. Results from logistic regression model showed that peak GH were negatively associated with hyperuricemia after controlling for age, gender, tanner stage, BMI SDS, IGF-1, blood pressure, HOMA-IR, lipids status. These data indicate that lower peak GH is positively associated with hyperuricemia in obese children and adolescents without known hypothalamic/pituitary disease after controlling BMI and insulin resistance, as well as other cardiometabolic risk factors.
Highlights
As one of the recognized public health problems, childhood obesity has reached epidemic levels globally
Despite many evidences admitting that uric acid is a cardiometabolic risk factor, and obesity-related hyposomatotropism is associated with classical risk factors for cardiovascular disease, to best of our knowledge, studies focusing on the association between obesity-related hyposomatotropism and
Obese subjects had lower peak GH on the arginine-levodopa stimulation test, and it had lower insulin-like growth factor 1 (IGF-1) and high density lipoprotein cholesterol (HDL-C) compared with the control group
Summary
As one of the recognized public health problems, childhood obesity has reached epidemic levels globally. Apart from multiple obesity-related metabolic complications, it has been firmly established that obesity is characterized by the reduced basal and pulsatile release of growth hormone(GH)[1,2,3] as well as the decreased stimulated GH release[4,5,6] in both children and adults. This GH deficiency associated with obesity is relative and is reversible with weight loss[3,7]. The purpose of this study is to investigate the association between peak stimulated GH and serum uric acid level in obese children and adolescents
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