Reduced parietal alpha power and psychotic symptoms: Test-retest reliability of resting-state magnetoencephalography in schizophrenia and healthy controls

Abstract

BackgroundDespite increased reporting of resting-state magnetoencephalography (MEG), reliability of those measures remains scarce and predominately reported in healthy controls (HC). As such, there is limited knowledge on MEG resting-state reliability in schizophrenia (SZ). MethodsTo address test-retest reliability in psychosis, a reproducibility study of 26 participants (13-SZ, 13-HC) was performed. We collected eyes open and eyes closed resting-state data during 4 separate instances (2 Visits, 2 runs per visit) to estimate spectral power reliability (power, normalized power, alpha reactivity) across one hour and one week. Intraclass correlation coefficients (ICCs) were calculated. For source modeling, we applied an anatomically constrained linear estimation inverse model known as dynamic statistical parametric mapping (MNE dSPM) and source-based connectivity using the weighted phase lag index. ResultsAcross one week there was excellent test-retest reliability in global spectral measures in theta-gamma bands (HC ICCAvg = 0.87, SZ ICCAvg = 0.87), regional spectral measures in all bands (HC ICCAvg = 0.86, SZ ICCAvg = 0.80), and parietal alpha measures (HC ICCAvg = 0.90, SZ ICCAvg = 0.84). Conversely, functional connectivity had poor reliability, as did source spectral power across one hour for SZ. Relative to HC, SZ also had reduced parietal alpha normalized power during eyes closed only, reduced alpha reactivity, and an association between higher PANSS positive scores and lower parietal alpha power. ConclusionsThere was excellent to good test-retest reliability in most MEG spectral measures with a few exceptions in the schizophrenia patient group. Overall, these findings encourage the use of resting-state MEG while emphasizing the importance of determining reliability in clinical populations.