Reduced metabolic rate accompanies the hemorrhage-induced hypothermia in conscious rats

Abstract

The mechanism for the hemorrhage-induced drop in body temperature is unknown. This study determined the alterations in cutaneous heat exchange and metabolic heat production caused by a moderate hemorrhage in conscious rats. Chronically instrumented rats were subjected to a 16 ml/kg hemorrhage, followed by a 4-h recovery period, while monitoring body core temperature and cutaneous temperature. Cutaneous heat transfer was disrupted by housing the animals at an elevated (28°C) ambient temperature. A separate group of experiments measured the change in oxygen consumption in the post-hemorrhage period. Moderate hemorrhage caused a drop in body core temperature which stabilized at 0.7±0.3°C below control in the second hour following hemorrhage. Disruption of cutaneous heat exchange by reducing the thermal gradient did not diminish the hemorrhage-induced hypothermia. Hemorrhage caused a significant decline of oxygen consumption (−0.21±0.05 ml O 2/g per h). This 16% drop in resting oxygen consumption was prevented by immediately retransfusing the aspirated blood back into the rat. These data indicate that a decrease in metabolic heat production mediates the drop in body core temperature caused by moderate hemorrhage in conscious rats.