Reduced kinetic schemes of short-term synaptic plasticity in inhibitory network models

Abstract

GABAergic, inhibitory interneurons are critical controllers of brain rhythms. Short-term synaptic plasticity affects neuronal network dynamics that give rise to these rhythms. We develop a protocol to fit a three-state phenomenological kinetic scheme to a more complex six-state kinetic scheme that describes synaptic depression. We are able to capture inhibitory network dynamics using our “reduced” simpler scheme as compared with using the more complex scheme. Using such simpler schemes, we will be able to explore the effects of short-term depression as described by more complex kinetic schemes on network dynamics.