Reduced In-Hospital Mortality Following Intracoronary Streptokinase Treatment of Acute Myocardial Infarction

Abstract

Reduced short-term mortality following thrombolytic treatment of acute myocardial infarction has been reported by earlier studies. This study was per formed to compare data from our institution with such results. From January, 1984, through January, 1986, a total of 628 consecutive pa tients were admitted with acute myocardial infarction. Ninety-one patients (Group A) underwent intracoronary streptokinase (IC-SK) infusion to the in farct-related vessel with a total dose of 440,000 units. The average timing for this intervention from the onset of chest pain was 4.1 ±2.7 hours. Successful recanalization was achieved in 71 of 91 patients (78%). Patients seventy-five years of age or older were not offered IC-SK infusion. In this group, most candidates suitable for coronary angioplasty or bypass surgery had the proce dure within the same hospital admission. The remaining 537 patients (Group B) underwent conventional medical therapy during their hospitalization. In-hospital mortality for Group A was reported in 4 of 91 patients (4.4%) versus 100 of 537 patients (18.6%) from Group B. These results seem to con form with earlier data that indicate a reduced short-term in-hospital mortality from acute myocardial infarction following IC-SK treatment. Besides recanali zation, this beneficial effect in Group A could also be attributed to earlier inter ventions by revascularization procedures in the majority of patients after recognition of the extent of their coronary artery disease.