Abstract
Abstract Purpose: Preoperative chemoradiation is standard therapy for esophageal cancer, but significant treatment-related toxicities are common. We sought to identify predictors of severe (≥ grade 3) acute toxicity. Patients and Methods: We retrospectively reviewed 293 patients treated with chemoradiation for nonmetastatic esophageal cancer at a single institution in 2008–2011; during this period radiation was delivered as intensity-modulated radiation therapy (IMRT; n = 170) or proton beam therapy (PBT; n = 124). Acute toxicities during and after radiation were graded with the National Cancer Institute Common Terminology Criteria for Adverse Events v4.0. Fisher's exact tests were used to assess associations between categorical variables. A Cox proportional hazard model was used to assess the influence of patient, tumor, and other factors on the occurrence of any severe toxicity. Results: Multivariate analysis adjusted for tumor volume and mean esophageal dose showed that predictors of two or more severe...
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