Abstract
BackgroundTo date, there has been no studies to evaluate the incidence of Crohn’s disease in systemic sclerosis patients. The goals of this study were to evaluate the incidence of Crohn’s disease and its relationship with sex and age in patients with systemic sclerosis.MethodsWe enrolled patients with systemic sclerosis and controls from Taiwan’s Registry of Catastrophic Illness Database and National Health Insurance Research Database. Every systemic sclerosis patient was matched to at most three controls by sex, age, month and year of initial diagnosis of systemic sclerosis. The standardized incidence ratio (SIR) of Crohn’s disease in systemic sclerosis patients, and 95 % confidence interval (95 % CI) were calculated. Cox hazard regression was used to calculate the hazard ratio (HR).ResultsThe study enrolled 2,829 patients with systemic sclerosis and 8,257 controls. Male and female patients with systemic sclerosis both had lower rates of incident Crohn’s disease (SIR: 0.18, 95 % CI = 0.05–0.62; SIR: 0.10, 95 % CI = 0.05–0.21, respectively). The risk of incident Crohn’s disease in systemic sclerosis was still lower than in controls when we stratified the patients according to their ages. In Cox hazard regression, the hazard rates of Crohn’s disease were lower in systemic sclerosis patients after adjusting for genders and ages (HR: 0.12, 95 % CI = 0.06–0.21, p < 0.001).ConclusionsSystemic sclerosis is associated with decreased incidence of, irrespective of sex and age of the patients.
Highlights
To date, there has been no studies to evaluate the incidence of Crohn’s disease in systemic sclerosis patients
There is an increasingly number of reports showing coexisting medical diseases such as systemic lupus erythematosus [2] and autoimmune thyroid disease associated with systemic sclerosis [3]
Another database acquired from the National Health Research Institutes (NHRI) was the Registry of Catastrophic Illness that included information of all 23 million Taiwanese citizens
Summary
There has been no studies to evaluate the incidence of Crohn’s disease in systemic sclerosis patients. The goals of this study were to evaluate the incidence of Crohn’s disease and its relationship with sex and age in patients with systemic sclerosis. Systemic sclerosis is a multisystem autoimmune disease characterized by endothelial dysfunction, widespread obliterative vasculopathy, and excessive collagen deposition in affected organs, culminating in tissue fibrosis [1]. It is associated with autoantibodies [1]. Another study showed reduced risk of inflammatory bowel disease in the family members of patients with systemic sclerosis [4]. We conducted this study to explore the incidence of Crohn’s disease and its relationship with sex and age in systemic sclerosis patients
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