Abstract
s / Toxicology Letters 229S (2014) S40–S252 S73 to increase the cytotoxicity of trimethoprim in MDR1 transfected cells. In conclusion, steviol may act as MDR1 inhibitor and BCRP substrate. In levels that couldphysiologicallyoccur in intestineafter single oral administration, steviol would be capable to enhance the MDR1-mediated cytotoxicity and influence the intestinal absorption of trimethoprim. The study was supported by Charles University in Prague (project SVV 260 064) and GACR project no. 303/12/G163. http://dx.doi.org/10.1016/j.toxlet.2014.06.283
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