Abstract
A new electrochemical sensor constructed using reduced graphene oxide/Ti-based metal–organic framework (RGO/Ti-MOF)-modified glassy carbon electrode (GCE) has been introduced for electro-catalytic oxidation and determination of Propranolol, a most used β-adrenergic receptor. Synthesized RGO/Ti-MOF composite as a synergistic catalyst has very active sites and great ability for electron transfer to oxidized Propranolol in phosphate buffer solution (PBS, pH 7). The oxidation over-potential of Propranolol decreased significantly, and its peak currents increased greatly at the modified electrode (GCE/RGO/Ti-MOF). The synthesized GO and Ti-MOF were identified by various methods. The calibration curve of Propranolol was linear in the range of 0.01–10 µM, and the detection limit was 0.008 µM. Finally, the electrochemical sensor was used for the quantification of Propranolol in tablet and urine samples.
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More From: Journal of Materials Science: Materials in Electronics
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