Abstract
ObjectiveInvolvements of microRNA-22 (miR-22) in cancer development have attracted much attention, but its role in tumorigenesis of gastric cancer is still largely unknown. Therefore, the aim of this study was to investigate the expression patterns and clinical implications of miR-22 in gastric cancer.MethodsQuantitative RT-PCR was performed to evaluate the expression levels of miR-22 in 98 pairs of gastric cancer and normal adjacent mucosa.ResultsCompared with normal adjacent mucosa, miR-22 expression was significantly downregulated in gastric cancer tissues (P < 0.001). Of 98 patients with gastric cancer, 58 (59.2%) were placed in the low miR-22 expression group and 40 (40.8%) were placed in the high miR-22 expression group. In addition, tumors with low miR-22 expression had greater extent of lymph node metastasis (P = 0.02) and distant metastasis (P = 0.01), and were at a worse stage (P = 0.01) than the tumors with high miR-22 expression. Moreover, the gastric cancer patients with low miR-22 expression had shorter overall survival than those with high miR-22 expression (P = 0.03). MiR-22, determined by multivariate analysis, was an independent prognostic factor for patients with gastric cancer.ConclusionOur data offer the convincing evidence that the reduced expression of miR-22 was significantly associated with malignant development of gastric cancer and may be a novel prognostic marker of this disease. miR-22 might have potentials in the application of cancer therapy for patients with gastric cancer.
Highlights
Gastric cancer is the fourth most prevalent forms of human cancers and the second leading cause of cancerrelated death in the world, especially in East Asian countries
We found that the downregulation of miR-206 was significantly correlated with tumor progression and may be a potent prognostic marker of gastric cancer [15]
Because of its involvement in several tumors in digestive system, we hypothesized that miR-22 might play a role in gastric cancer
Summary
Gastric cancer is the fourth most prevalent forms of human cancers and the second leading cause of cancerrelated death in the world, especially in East Asian countries. According to its histological subtypes, gastric cancer can be divided into two groups: the intestinal type and the diffuse type The former is characterized by expansive growth and liver metastasis; whereas the latter is characterized by infiltrative growth and peritoneal dissemination [2,3,4]. MiRNAs function as regulators of approximately 60% protein-coding genes’ expression mainly at the posttranscriptional level by binding to the sequences in the 3′ untranslated regions (3′-UTR) of their targeted mRNAs resulting in translational repression or gene silencing [12] As they are involved in regulation of wide array of biological processes including cell proliferation, differentiation, apoptosis, metastasis, angiogenesis and immune response, miRNAs have been considered to be new approaches of tumor biomarkers for early cancer diagnosis and prognosis. The aim of the present study was to investigate the expression patterns and clinical implications of miR-22 in gastric cancer
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