Abstract
Background: The role of neurotrophins in directing brain growth and neuronal functioning is being increasingly recognized. Neurotrophins not only play an important role in cellular proliferation, migration, and phenotypic differentiation and/or maintenance in the developing central nervous system but also their presence is required in the adult CNS for maintenance of neuronal functions, structural integrity of neurons, and neurogenesis, which suggests that neurotrophins are biologically significant over the entire lifespan.
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