Abstract
Observations from a genome-wide comparison of Drosophila melanogaster and Drosophila yakuba are consistent with a severe reduction in the efficacy of selection in the absence of crossing over, resulting in the accumulation of deleterious mutations in these regions.
Highlights
The recombinational environment is predicted to influence patterns of protein sequence evolution through the effects of Hill-Robertson interference among linked sites subject to selection
Patterns of molecular evolution can be profoundly different between loci that differ in their recombinational environment
Because the efficacy of selection on a mutation is a function of the product of Ne and the selection coefficient on a mutation (s), this linkage affects the probability of fixation of a new mutation [2]; favourable mutations are less likely to reach fixation, whereas the opposite is true for deleterious mutations
Summary
The recombinational environment is predicted to influence patterns of protein sequence evolution through the effects of Hill-Robertson interference among linked sites subject to selection. In freely recombining regions of the genome, selection should more effectively incorporate new beneficial mutations, and eliminate deleterious ones, than in regions with low rates of genetic recombination. Patterns of molecular evolution can be profoundly different between loci that differ in their recombinational environment. This is due to Hill-Robertson interference [1], whereby any locus linked to another that is under directional selection experiences a reduction in effective population size (Ne). Recombination reduces the effect of this interference, increasing Ne and the efficacy of selection. We would expect higher levels of adaptation, and lower rates of fixation of Genome Biology 2007, 8:R18
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