Abstract
BackgroundAuditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, however, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia.MethodHigh-resolution MR images were obtained in 49 first-episode schizophrenia (FES) patients and 50 well-matched healthy controls (HCs). Among the FES patients, 18 suffered persistent AVHs (“auditory hallucination” AH group), and 31 never experienced AVHs (“no hallucination” NH group). The severity of AVHs was rated by the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness differences among the three groups and their association with AVHs severity were examined.ResultsCompared to both HCs and NH patients, AH patients showed lower cortical thickness in the right Heschl’s gyrus. The degree of reduction in the cortical thickness was correlated with AVH severity in the AH patients.ConclusionsAbnormalities of cortical thickness in the Heschl’s gyrus may be a physiological factor underlying auditory verbal hallucinations in schizophrenia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12888-015-0546-2) contains supplementary material, which is available to authorized users.
Highlights
Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, brain abnormalities underlying AVHs remain unclear
The degree of reduction in the cortical thickness was correlated with AVH severity in the auditory hallucination (AH) patients
There were no significant differences among the groups regarding age, sex, and years of education
Summary
Auditory verbal hallucinations (AVHs) represent one of the most intriguing phenomena in schizophrenia, brain abnormalities underlying AVHs remain unclear. The present study examined the association between cortical thickness and AVHs in first-episode schizophrenia. Schizophrenia is one of the most debilitating mental illnesses [1], characterized by positive symptoms, negative symptoms and cognitive deficits. As a core positive symptom, auditory verbal hallucinations (AVHs) is an important diagnostic criterion for schizophrenia [2], which has been shown to be closely related to schizophrenia patients’ long-term social functioning and quality of life [3]. Previous neuroimaging studies have revealed widespread morphological abnormalities associated with AVHs, such as gray matter loss in the frontal [4, 5], insular [6], and anterior/posterior cingulate [7, 8] cortices.
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