Abstract
Bulk cerebrospinal fluid (CSF) production was measured in rabbits by ventriculocisternal perfusion of [ 14C]inulin. Intraventricular or intravenous infusion of carbamylcholine or acetylcholine produced a dose-related reduction in the CSF formation by as much as 55%. The effect was antagonized by atropine but not by hexamethonium. Carbachol potentiated the reduction induced by sympathetic nerve stimulation or noradrenaline to an equal extent. The results show that the bulk CSF production is markedly reduced through cholinergic mechanisms involving the muscarinic type of receptors in the cholinergically innervated choroid plexus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
