Reduced brain glucose metabolism in hypertension

Abstract

After correcting for multiple comparison, in subjects with high WML burden (n1⁄415) higher Bvol was related to higher mean systolic (rho1⁄4.62, p1⁄4.02), mean diastolic (rho1⁄4.61, p1⁄4.02) and mean daily MAP (mean arterial pressure) (rho1⁄4.63, p1⁄4.01) as derived from 24-hour ambulatory blood pressure monitoring. The relationship between systolic, diastolic, MAP derived from one time office measurements and Bvol, were weaker and did not survive the Bonferroni correction. There was no relationship between blood pressure measurements and Bvol in the subgroup with mild or absent WML. These findings support the notion that in brain with vascular damage higher BP is related to less atrophy. Moreover, they confirm that 24hour ABPM measurements are better predictor of brain volumes than one-time, in office BP examination.