Abstract
Mung bean seed coat (MBSC) is a healthcare product in Asian countries. The aim of this study was to investigate the effect of an MBSC ethanol extract on the bioavailability of cyclosporine A (CsA) in rats. Rats were orally dosed with CsA alone or in combination with MBSC ethanol extracts (500 mg/kg, p.o.). The blood levels of CsA were assayed by liquid chromatography with an electrospray ionization source and tandem mass spectrometry (LC-MS/MS). The everted rat intestinal sac technique was used to determine the influence of MBSC on the absorption of CsA. The results reveal that combined CsA intake with MBSC decreased the Cmax, AUC0-t, t1/2z and MRT0-t values of CsA by 24.96%, 47.28%, 34.73% and 23.58%, respectively (P<0.05), and significantly raised the CL/F by 51.97% (P<0.01). The in vitro results demonstrated that significantly less CsA was absorbed (P<0.05). The overall results indicate that after being concomitantly ingested, MBSC reduced the bioavailability of CsA, at least partially, in the absorption phase.
Highlights
In daily practice, drugs are often taken simultaneously with foods or nutriments
The purpose of this study was to verify the pharmacokinetic effects of mung bean seed coat (MBSC) on Cyclosporine A (CsA)
The results reveal that there were no significant differences in Lactate dehydrogenase (LDH) activity at 30, 60, 90 and 120 min, while a significant difference was found at 180 min, suggesting that the everted gut sacs began to lose viability after 120 min
Summary
Drugs are often taken simultaneously with foods or nutriments. food-drug interactions (FDIs), with commonly overlooked hidden risks, unintentionally result in therapeutic failure or increasedX. Drugs are often taken simultaneously with foods or nutriments. Food-drug interactions (FDIs), with commonly overlooked hidden risks, unintentionally result in therapeutic failure or increased. Liu which are prone to inducing acute cellular rejection, lead to hepatotoxicity, nephrotoxicity and neurotoxicity (Kuypers, 2008). Yang (2002) reported six patients who had received a renal transplantation and suffered from graft rejection after concomitantly drinking mung bean soup. The trough concentrations of CsA decreased from (390.00±112.21) ng/mL before mung bean food intake to (287.33±94.21) ng/mL (P < 0.001) after
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