Abstract
Reduced BCR Signaling and a Metabolic Shift Accompanies Malignant Progression of Follicular Lymphoma: A Lesson from Transcriptomics
Highlights
Follicular Lymphoma (FL) is the commonest indolent non-Hodgkin lymphomas (NHL), a low-grade germinal centre-derived tumour characterized by the deregulation of several driver genes and signalling pathways involved in the pathogenesis [4,5,6,7]
From the analysis of gene expression profile (GEP) emerged the existence of at least 2 genetic subtypes of DLBCL that can be tracked to different stages of B-cell differentiation, resembling either germinal center B-cells (GCB) or activated B-cells (ABC) [10]
A role of a specific K+ channels, Kv 11.1, known as hERG1, has recently been associated with chemoresistance and invasiveness of leukemic blasts [21,22]. Based on these premises and with the aim to identify different profiles related to the progression of the disease and their potential translational relevance, we have determined the ICT-GEP of FL, compared with the one of FL after the relapse, and with the more aggressive DLBCL
Summary
FL is the commonest indolent NHL, a low-grade germinal centre-derived tumour characterized by the deregulation of several driver genes and signalling pathways involved in the pathogenesis [4,5,6,7]. The characterization of the gene expression profile (GEP) and the identification of specific signatures is emerging as a novel tool for the classification of nonHodgkin lymphoma, the identification of different molecular subtypes and the understanding of neoplastic B-cell biology [10].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
