Abstract
In order to solve the defects of chemotherapeutics, numerous collaborative therapy systems have been developed according to the characteristics of tumor microenvironment. Herein, a targeting redox-sensitive micellar system (DOX/FCH) composed of ferrocene (Fc) and hyaluronic acid (HA) was prepared to deliver doxorubicin (DOX) for synergetic chemotherapy and chemodynamic therapy (CDT). DOX/FCH could accurately target the tumor site through high affinity between HA and high-expressed CD44 receptors in human cervical carcinoma (HeLa) cells. The appropriate particle size made it easier for cells to take up the micelles. The DOX released from DOX/FCH reached about 50% in 2 h, because the disulfide bonds were depolymerized in reducing environment which simulate the tumor intracellular environment. Moreover, the production of hydroxyl radical (·OH) was detected both extracellular and intracellular, which indicated that FCH could exert the CDT effect through Fenton reaction to enhance the chemotherapy of DOX. The good biocompatibility in 3T3 cells as well as the obvious cytotoxicity in HeLa cells demonstrated that FCH had the possibility of becoming an excellent nanocarrier. Also, the cytotoxicity of DOX/FCH also confirmed the synergetic effect of CDT of FCH and chemotherapy of DOX. Therefore, DOX/FCH shows great potential in the application of improving the efficacy of combined chemotherapy and CDT.
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