Abstract
The synthesis and physico-chemical characterization of Fe(II) and Mn(II) complexes of 4,6-di- tert-butyl-3[(2-hydroxyethyl)sulphanyl]-1,2-dihydroxybenzene (HL I) and 2-amino-4,6-di- tert-butylphenol (HL II) were carried out. Antibacterial activity of the Co(II), Fe(II) and Mn(II) complexes was evaluated in comparison with Cu(II) complexes and three common antibiotics; it was found to follow the order: (1) Сu(L I) 2 > Сo(L I) 2 > Fe(L I) 2 ⩾ Mn(L I) 2 > HL I; (2) Сu(L II) 2 > Сo(L II) 2 > HL II > Fe(L II) 2 ⩾ Mn(L II) 2; and their reducing ability (determined electrochemically) followed the same order. Spectrophotometric investigation was carried out in order to estimate the rate of the reduction of bovine heart сytochrome c with the ligands and their metal(II) complexes. NADPH:cytochrome P450-reductase was found to increase the rate of сytochrome c reduction with HL I and HL II ligands, while adrenodoxin in couple with NAD(P)H: adrenodoxin reductase had no substantial effect thereon. It was shown that the reduction of сytochrome c with these compounds cannot be related solely to the facility of their oxidation оr ionization.
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