Redox Status and Proteostasis in Ageing and Disease.

Federica Rizzi,Gerasimos P Sykiotis,Ioannis P Trougakos,Gianfranco Pintus

doi:10.1155/2016/7476241

Abstract

Morbidity and mortality from preventable, noncommunicable chronic disease (NCD) threatens the health of our populations and our economies. The accumulation of vast amounts of scientific knowledge has done little to change this. New and innovative thinking is essential to foster new creative approaches that leverage and integrate evidence through the support of big data, technology, and design thinking. The purpose of this paper is to summarize the results of a consensus meeting on NCD prevention sponsored by the International Olympic Committee (IOC) in April 2013. Within the context of advocacy for multifaceted systems change, the IOC's focus is to create solutions that gain traction within health care systems. The group of participants attending the meeting achieved consensus on a strategy for the prevention and management of chronic disease that includes the following: 1. Focus on behavioral change as the core component of all clinical programs for the prevention and management of chronic disease. 2. Establish actual centers to design, implement, study, and improve preventive programs for chronic disease. 3. Use human-centered design (HCD) in the creation of prevention programs with an inclination to action, rapid prototyping and multiple iterations. 4. Extend the knowledge and skills of Sports and Exercise Medicine (SEM) professionals to build new programs for the prevention and treatment of chronic disease focused on physical activity, diet, and lifestyle. 5. Mobilize resources and leverage networks to scale and distribute programs of prevention. True innovation lies in the ability to align thinking around these core strategies to ensure successful implementation of NCD prevention and management programs within health care. The IOC and SEM community are in an ideal position to lead this disruptive change. The outcome of the consensus meeting was the creation of the IOC Non-Communicable Diseases ad hoc Working Group charged with the responsibility of moving this agenda forward.

Highlights

This special issue features a collection of reviews and original articles covering distinct aspects of the effect of redox imbalance on the integrated complex of adaptive molecular signaling required to actively maintain proteome stability and functionality
In their review entitled “It Is All About U(biquitin): Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease” A
Tramutola et al discuss the impairment of the proteasome system as a consequence of oxidative stress and how this contributes to Alzheimer disease (AD) onset and progression

Summary

Introduction

In their review entitled “It Is All About U(biquitin): Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease” A. This special issue features a collection of reviews and original articles covering distinct aspects of the effect of redox imbalance on the integrated complex of adaptive molecular signaling required to actively maintain proteome stability and functionality.

Results

Conclusion