Abstract
The redox state of the human body is the result of a complex influence of enzymes, metabolites, biogenic elements, and endogenous lifestyle factors. With age, unfavorable changes occur and degenerative and pathogenic processes are unlocked, various diseases appear, such as osteoporosis. In the present work, the radical scavenging activity (RSA%) and the blood serum conclusions of copper and magnesium were investigated in patients with osteoporosis of the hip, as well as in patients with osteoporosis of the lumbar spine. 66 menopausal and postmenopausal women aged 63.41±7.81 were investigated - newly diagnosed with osteoporosis and controls. Exclusion criteria were as follows: diabetes, endocrine and liver disease; intake of estrogenic and biogenic elements. Bone mineral density (BMD) was measured in all patients using dual-energy X-ray absorptiometry (DEXA). Patients with T-Score ≤ -2.5 were divided into two groups – with osteoporosis of the hip and with osteoporosis of the lumbar spine. A control group with T-Score > -1.0 was formed. Serum RSA% was established using the experimental method for determining antioxidants ABTS decolonization assay. Serum copper and magnesium levels were determined using atomic absorption analysis. According to the RSA% indicator, we obtained the following values: 73.30 ± 9.84 in the group with lumbar vertebrae osteoporosis; 68.87 ± 13.26 in the hip osteoporosis group; 55.67 ± 1.37 in the control group. When monitoring the radical scavenging activity, depending on the localization of the disease, we detected higher values in patients with osteoporosis of the lumbar spine. Serum copper and magnesium concentrations of all patients were elevated relative to the controls, but there was no statistical difference between groups with different disease localization. Patients with osteoporosis were found to have a higher protective antioxidant capacity in response to increased free-radical processes in the body and cellular metabolic disorders.
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