Abstract
Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.
Highlights
There has been treatment of neurotoxicity and neurodegenerative diseases involving reactive oxygen species (ROS) and oxidative stress (OS)
The redox approach comprises a unifying theme which can be applied to a large number of illnesses in this class, including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and tardive dyskinesia
DOWN’S SYNDROME (DS) brain tissue is considered to be susceptible to oxidative injury, mainly because the increased SOD activity is not followed by an adaptive rise in enzymes that metabolize hydrogen peroxide [52]
Summary
There has been treatment of neurotoxicity and neurodegenerative diseases involving reactive oxygen species (ROS) and oxidative stress (OS). Changes in AO defense mechanisms and resulting increased lipid peroxidation are involved in the pathogenesis [11]. There is evidence of lipid peroxidation and nitrite formation during seizure activity that could be responsible for neuronal damage during epilepsy.
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