Abstract
Although biomimetic or bioinspired synthesis is a widely used and powerful strategy for the efficient synthesis of naturally occurring molecules, prebiomimetic synthesis or prebioinspired organic synthesis has remained unprecedented. Herein, we report the first prebiomimetic synthesis of α-iminonitriles, N-monosubstituted and N,N-disubstituted α-cyanoenamines, and N-acyl derivatives from amides. The method is inspired by the possible prebiotic pathways put forward by Saladino/Di Mauro and Springsteen/Krishnamurthy–Leszczynski/Gu and features triflic anhydride (Tf2O)-mediated redox-neutral cyanation of secondary amides with trimethylsilyl cyanide (TMSCN) under mild conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
