Abstract
Male infertility, a relatively common and multifactorial medical condition, affects approximately 15% of couples globally. Based on WHO estimates, a staggering 190 million people struggle with this health condition, and male factor is the sole or contributing factor in roughly 20–50% of these cases. Nowadays, urologists are confronted with a wide spectrum of conditions ranging from the typical infertile male to more complex cases of either unexplained or idiopathic male infertility, requiring a specific patient-tailored diagnostic approach and management. Strikingly enough, no identifiable cause in routine workup can be found in 30% to 50% of infertile males. The medical term male oxidative stress infertility (MOSI) was recently coined to describe infertile men with abnormal sperm parameters and oxidative stress (OS), including those previously classified as having idiopathic infertility. OS is a critical component of male infertility, entailing an imbalance between reactive oxygen species (ROS) and antioxidants. ROS abundance has been implicated in sperm abnormalities, while the exact impact on fertilization and pregnancy has long been a subject of considerable debate. In an attempt to counteract the deleterious effects of OS, urologists resorted to antioxidant supplementation. Mounting evidence indicates that indiscriminate consumption of antioxidants has led in some cases to sperm cell damage through a reductive-stress-induced state. The “antioxidant paradox”, one of the biggest andrological challenges, remains a lurking danger that needs to be carefully avoided and thoroughly investigated. For that reason, oxidation-reduction potential (ORP) emerged as a viable ancillary tool to basic semen analysis, measuring the overall balance between oxidants and antioxidants (reductants). A novel biomarker, the Male infertility Oxidative System (MiOXSYS®), is a paradigm shift towards that goal, offering a quantification of OS via a quick, reliable, and reproducible measurement of the ORP. Moderation or “Μέτρον” according to the ancient Greeks is the key to successfully safeguarding redox balance, with MiOXSYS® earnestly claiming its position as a guarantor of homeostasis in the intracellular redox milieu. In the present paper, we aim to offer a narrative summary of evidence relevant to redox regulation in male reproduction, analyze the impact of OS and reductive stress on sperm function, and shed light on the “antioxidant paradox” phenomenon. Finally, we examine the most up-to-date scientific literature regarding ORP and its measurement by the recently developed MiOXSYS® assay.
Highlights
Infertility, the incapacity to conceive after one year of regular, unprotected sexual intercourse, affects approximately one out of five of couples worldwide [1,2,3]
Subtle balance tility, urologists need toto embark upon continuous endeavors towards subtle balance in tility, urologists need to embark embark upon continuous endeavors towards subtle balance in redox state was considered taken around noon afternoon in was considered aa quick quick lunch lunchbe taken around noon or or early early afternoon in words, it co state strictly characterized by mean
This review summarizes all the existing evidence relevant to redox balance in male
Summary
Infertility, the incapacity to conceive after one year of regular, unprotected sexual intercourse, affects approximately one out of five of couples worldwide [1,2,3]. Nowadays,quote there growing awareness that uncontrolled therapy is considered aone quick lunch taken aro Such an approach deemed risky, and is alnotsages devoid of risks. Transferring theconcept concept ofmoderation moderation to male infertility, urologists need embark upon continuous endeavors asubtle subtle balance in tha detrimental, even ififneed that thing is generally considered beneficial. Was considered taken around noon afternoon in was considered aa quick quick lunch lunchbe taken around noon or or early early afternoon in words, it co state strictly characterized by mean This summarizes all the existing relevant redox balance in inancient areview that parallels the antioxidant administration.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
