Abstract
The carbonized boronic acid-conjugated fluorescent carbon nanoparticles (FNPs) were crosslinked with carbonized dopamine-conjugated hyaluronic acid (HA) via the diol boronic acid-linked catechol groups [C-FNP] as extracellular targeting ligands and pH responsiveness. Into that C-FNP, the redox-responsive MnO2 nanosheets were loaded to demonstrate quenching effect, which recovered after glutathione (GSH) treatment. The MnO2-loaded C-FNP showed excellent stability and tumor-targeting ability guided to the localized tumor using “on–off” fluorescent switch. Furthermore, paclitaxel (PTX) inside the MnO2-loaded C-FNP performed in vitro and in vivo bioimaging and chemotherapeutic activities analyzed towards cancer and non-cancerous cells.
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