Abstract
Redox and pH dual-responsive supramolecular micelles are prepared through a traditional polymer block and a supramolecular block to completely release the drugs. Ferrocene-introduced and hydrophobic-modified β-cyclodextrin (β-CD-Fc-Ace, where β-CD, Fc, and Ace refer to β-cyclodextrin, ferrocene, and acetal, respectively) is used to build the supramolecular block. Adamantane-terminated poly(ethylene glycol) methyl ether (mPEG-Ada) is the traditional polymer block. The average diameter of supramolecular micelles is ≈100 nm. Supramolecular micelles are able to control the release of the drugs in the cancer cells due to pH and redox microenvironments.
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