REDOX ALTERATIONS IN PREGNANT WOMEN: ANTIOXIDANT EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS (DC.) STAPF) ALTERAÇÕES REDOX EM GESTANTES: EFEITO ANTIOXIDANTE DO CAPIM-LIMÃO (CYMBOPOGON CITRATUS (DC.) STAPF)

Abstract

Purpose: This study aimed to verify the redox profile of different gestational phases of pregnant women, in addition to the antioxidant potential of the Cymbopogon citratus leaves infusion. Methods: The infusion characterization was performed by measuring total phenolics, flavonoids and condensed tannins levels. The oxidative damage markers to lipids and proteins in plasma and erythrocytes were evaluated by measuring the TBARS and carbonylated proteins (CP) levels and antioxidant activity by GSH levels. The antioxidant effects of the infusion (20 g/L) were evaluated by measuring the same markers after the pregnant women erythrocytes incubation with the same infusion. The phytochemicals with the highest concentration founded in infusion were flavonoids, followed by tannins and phenolics. Results: It was observed an increase in TBARS levels in the 2 nd gestational phase in plasma, concomitant with a decrease in GSH levels in the 2 nd and 3 rd phases, and CP in the 1 st and 4 th gestational phases in relation to control. It was observed a decrease in all markers levels in erythrocytes in the 1 st and 2 nd phases. Analyzing the antioxidant potential of the infusion on erythrocytes, it was observed a decrease in TBARS concomitant with an increase in GSH levels, being little effective in reversing protein damage. Conclusion: Thus, it is suggested that the infusion could be used as adjuvant to vitamin supplements recommended during pregnancy.