Abstract
Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with increased risk for cardiovascular disease and overall mortality. Excessive alcohol intake is a well-known risk factor for AF, but this correlation is less clear with light and moderate drinking. Besides, low doses of red wine may acutely prolong repolarization and slow cardiac conduction. Resveratrol, a bioactive polyphenol found in grapes and red wine, has been linked to antiarrhythmic properties and may act as an inhibitor of both intracellular calcium release and pathological signaling cascades in AF, eliminating calcium overload and preserving the cardiomyocyte contractile function. However, there are still no clinical trials at all that prove that resveratrol supplementation leads to improved outcomes. Besides, no observational study supports a beneficial effect of light or moderate alcohol intake and a lower risk of AF. The purpose of this review is to briefly describe possible beneficial effects of red wine and resveratrol in AF, and also present studies conducted in humans regarding chronic red wine consumption, resveratrol, and AF.
Highlights
Atrial fibrillation (AF) is the most common cardiac arrhythmia and has been associated with increased risk for ischemic heart disease, major cardiovascular events, stroke, heart failure, chronic kidney disease, peripheral arterial disease, sudden cardiac death, cardiovascular, and all cause mortality [1]
Resveratrol, a bioactive polyphenol that is found in grapes and red wine, has been linked to beneficial effects on cardiovascular diseases [14] and may exhibit antiarrhythmic properties [15,16]
The purpose of this review was to briefly describe possible beneficial effects of red wine and resveratrol in AF, and present studies conducted in humans regarding resveratrol/chronic red wine consumption and incident AF
Summary
Atrial fibrillation (AF) is the most common cardiac arrhythmia and has been associated with increased risk for ischemic heart disease, major cardiovascular events, stroke, heart failure, chronic kidney disease, peripheral arterial disease, sudden cardiac death, cardiovascular, and all cause mortality [1]. The pathophysiology behind AF onset after binge drinking (“holiday heart”) is not entirely elucidated and is likely multifactorial, encompassing direct (cytotoxic) and indirect (increased sympathetic and parasympathetic activity) mechanisms It has been postulated through animal models that both QT interval prolongation and shortening of the atrial effective refractory period might be related to AF onset after binge drinking [7,10]. Resveratrol, a bioactive polyphenol that is found in grapes and red wine, has been linked to beneficial effects on cardiovascular diseases [14] and may exhibit antiarrhythmic properties [15,16]. It is not known if the antiarrhythmic effects of resveratrol can counterpoise the proarrhythmic effects of alcohol intake. The purpose of this review was to briefly describe possible beneficial effects of red wine and resveratrol in AF, and present studies conducted in humans regarding resveratrol/chronic red wine consumption and incident AF
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