Red Seaweed-Derived Compounds as a Potential New Approach for Acne Vulgaris Care.

Adriana P Januário,Carina Félix,Rafael Félix,Marco F L Lemos,João Reboleira,Patrícia Valentão

doi:10.3390/pharmaceutics13111930

Adriana P Januário, Carina Félix + Show 4 more

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https://doi.org/10.3390/pharmaceutics13111930

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Abstract

Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroalgae are known producers of substances with bioactive properties, including anti-viral, antibacterial, antioxidant, and anti-inflammatory properties, among several others. In particular, red algae are rich in bioactive compounds such as polysaccharides, phenolic compounds, lipids, sterols, alkaloids, and terpenoids, conferring them antioxidant, antimicrobial, and anti-inflammatory activities, among others. Thus, the exploration of compounds from marine resources can be an appealing approach to discover new treatment options against AV. The aim of this work is to provide an overview of the current knowledge of the potentialities of red macroalgae in the treatment of AV by reviewing the main therapeutic targets of this disease, and then the existence of compounds or extracts with bioactive properties against them.

Highlights

IntroductionPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations
According to what has been mentioned, the goal of this review is to provide a compilation of compounds and extracts derived from red macroalgae that can hereafter be applied to Acne vulgaris (AV) research care
A thorough literature analysis revealed that the general pathogenesis of AV is well established and amply described, but there is not yet a consensus regarding the whole pathophysiology, mechanisms, and order of events that lead to AV lesions

Summary

Introduction

Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Acne vulgaris (AV) is a chronic disease of the pilosebaceous unit, and the most common skin disease in the world. It affects up to 85% of adolescents in the Occidental countries, and it can occur during adulthood in about 50% of people [1,2], having an incidence of nearly 9.4% of the worldwide population and being the eighth most prevalent disease in the world [3]. Acne deeply impacts quality of life through the manifestation of pimples, blackheads and scars on the face, upper chest and back, which can be painful and negatively affect the self-perception of beauty, leading to distress, anxiety, and depression [4,5,6]

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