Abstract
Propolis has various pharmacological properties of clinical interest, and is also considered a functional food. In particular, hydroalcoholic extracts of red propolis (HERP), together with its isoflavonoid formononetin, have recognized antioxidant and anti-inflammatory properties, with known added value against dyslipidemia. In this study, we report the gastroprotective effects of HERP (50–500 mg/kg, p.o.) and formononetin (10 mg/kg, p.o.) in ethanol and non-steroidal anti-inflammatory drug-induced models of rat ulcer. The volume, pH, and total acidity were the evaluated gastric secretion parameters using the pylorus ligature model, together with the assessment of gastric mucus contents. The anti-Helicobacter pylori activities of HERP were evaluated using the agar-well diffusion method. In our experiments, HERP (250 and 500 mg/kg) and formononetin (10 mg/kg) reduced (p < 0.001) total lesion areas in the ethanol-induced rat ulcer model, and reduced (p < 0.05) ulcer indices in the indomethacin-induced rat ulcer model. Administration of HERP and formononetin to pylorus ligature models significantly decreased (p < 0.01) gastric secretion volumes and increased (p < 0.05) mucus production. We have also shown the antioxidant and anti-Helicobacter pylori activities of HERP. The obtained results indicate that HERP and formononetin are gastroprotective in acute ulcer models, suggesting a prominent role of formononetin in the effects of HERP.
Highlights
Dyslipidaemia is a condition defined either by the high levels of total or low-density lipoprotein (LDL) cholesterol, and/or by the low levels of high-density lipoprotein (HDL)
We reported the gastroprotective effect of hydroalcoholic extracts of red propolis (HERP), and its predominant isoflavonoid formononetin, known for its hypolipidemia effects
Our results demonstrated that treating animals with
Summary
Dyslipidaemia is a condition defined either by the high levels of total or low-density lipoprotein (LDL) cholesterol, and/or by the low levels of high-density lipoprotein (HDL) Such lipid metabolic dysfunction, resulting from, e.g., lipid peroxidation or oxidative stress, plays an important role in the pathogenesis of atherosclerosis and other chronic diseases [1]. Channels) against exposure to endogenous and exogenous factors (e.g., non-steroidal anti-inflammatory drugs (NSAIDs), pepsin, bile acids, alcohol, stress, and trauma, Helicobacter pylori infection, hemorrhagic shock, sepsis, and burns) promote the development of gastric ulcers [36,37]. We proposed the in vivo characterization of the gastroprotective effects of HERP and formononetin, using an experimental rat model of gastric ulcer, as a suitable approach for phytomedical uses
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