RED MAN SYNDROME IN VANCOMYCIN CARE PATIENTS-A CRITICAL REVIEW

Abstract

Gram Positive bacterial species such as Streptococci, Staphylococci, Pneumococci and Methicillin Resistant Staphylococcus Aureus (MRSA) are still used extensively against vancomycin, a novel anti-bacterial agent produced about 7 decades ago. The bactericidal drug is responsible for two major reactions of hypersensitivity, namely Red Man Syndrome (RMS) and Anaphylaxis. RMS that occurs mainly due to a rise in infusion volume. This analysis focuses primarily on the facts to indicate RMS incidence. All available papers were compiled from PubMed and Google Scholar, and a comprehensive table with descriptions of all published articles from the past 8 years is listed. Of the 11 case reports that were released, nearly all adopted the Adverse Drug Reaction (ADR) protocol. This ADR may be caused by different routes of administration such as oral (PO), intea peritoneal (IP), intravenous (IV), topical powder, etc. Vancomycin-induced Red Man syndrome is a severe and fatal ADR that can cause complications if not treated on time, particularly in the paediatric population. However, to validate the proof, more confirmatory tests need to be carried out.