Abstract
Context: The Red Ear Syndrome” (RES) is a rare condition characterized by ear hyperemia associated with burning pain. This syndrome is classified into secondary and idiopathic forms, which pathophysiological mechanisms are still unclear. Idiopathic forms occur isolated or associated with primary headaches and secondary forms are associated to cervical disorders. The aim of this study is to report a case of RES related to migraine, the new published cases make this syndrome earn more attention and investigation. Case report: A 31-year-old woman presented with acute pain, edema and marked erythema, occasionally accompanied by hyperhidrosis and local burning. These episodes occurred spontaneously or were induced by triggers. During attacks, cooling was the only means of relief. The patient reported a clear association between RES and some migraine attacks. Extensive laboratory and radiological investigation showed no abnormalities. Conclusions: RES is mainly determined by sudden or induced attacks of burning pain and redness in the ear. Attacks can last from minutes to hours in conjunction with primary headaches. The uncertainty about the etiology of this syndrome is an obstacle to treatment.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
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