Abstract
Bariatric surgery is the most effective method for producing sustained weight loss, improving obesity-associated comorbidities and reducing inflammation in the morbidly obese population. The red cell distribution width (RDW) is a novel marker of inflammation that is usually reported as part of a complete blood count. In this study, we tested our hypothesis that red cell distribution width might represent a novel biomarker predictive of excess body-mass index loss (EBMIL) following laparoscopic Roux-en-Y gastric bypass (LRYGB). Five hundred and forty-seven LRYGB patients included from a single institution were individually reviewed, noting both preoperative RDW and percent excess BMI loss at 6months and 1year post-LRYGB (%EBMIL180 and %EBMIL365, respectively). Bivariate and multivariate linear regression analysis was conducted between age, gender, initial body-mass index (BMI0) and RDW and each of the two endpoints, to assess the independence of RDW as a predictor of postoperative success. The median RDW was 13.9 (13.3-14.6)%, and median EBMIL180 and EBMIL365 were 55.4 (45.2-66.7)% and 71.3 (58.9-87.8)%, respectively. After controlling for age, gender and BMI0, RDW was associated with %EBMIL365 (B=-1.4 [-2.8 to -0.002]%, P=.05), but not %EBMIL180 (B=-0.6 [-1.6 to 0.5]%, P=.30. Upon Kruskal-Wallis analysis, patients with a preoperative RDW>15.0% had significantly lower %EBMIL than those in the <13.0% (P<.001) and 13.0-15.0% (P<.01) strata. RDW is predictive of EBMIL at 1year following LRYGB. This represents a novel preoperative biomarker that may provide clinically useful prognostic information.
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