Red Cell Distribution Width and Contrast-Induced Nephropathy

Abstract

The recent report by Kurtul et al on ‘‘Red Cell Distribution Width (RDW) and Contrast-Induced Nephropathy (CIN)’’ is very interesting. A similar finding that RDW could be predictive for CIN was also reported by Akkoyun et al. There are some concerns regarding using RDW. First, RDW is a red blood cell parameter derived from automated hematology analyzers. The results from different measurement techniques can vary and Kurtul et al did not mention this limitation. Furthermore, fragmented red cells can influence RDW values. In addition to coronary heart problems, several conditions can also result in increased fragmented red cells. In an area with a high prevalence of inherited red blood cell disorders, especially thalassemia, a high RDW value is common despite the absence of cardiac problems. Due to the possible problem with RDW, some newer parameters such as RDWstandard deviation and RDW coefficient of variation should be considered for use instead.