Abstract
The purpose of this study was to examine the hypothesis that lower in n‐3 fatty acids and higher in trans fatty acids in red blood cell (RBC) were associated with the increased risk of MI, and fatty acid profiles could discriminate MI cases from controls as compared with established risk factors. Fifty cases with a first nonfatal MI and fifty age‐ and sex matched controls without MI were recruited. The Omega‐3 Index (the sum of EPA and DHA in RBC) was significantly lower in cases than controls (9.57 ± 0.28% vs. 11.81 ± 0.35%, P < 0.001), while total trans fatty acids were significantly higher (1.01 ± 0.04% vs. 0.56 ± 0.03%, P < 0.001). Omega‐3 Index was associated with decreased risk (OR 59.0; 95% CI: 0.03, 0.09; P = 0.001), while total trans fatty acids were associated with increased risk (OR 59.0; 95% CI: 11.32, 307.51; P < 0.001). The area under the receiver operating characteristic curve of fatty acid profiles was larger than traditional factors, suggesting that fatty acid profiles contributed significantly to the discrimination of MI case from controls as compared with the modified Framingham risk factors. In conclusion, higher Omega‐3 Index and lower trans fatty acids of RBC were associated with decreased risk of nonfatal MI, and fatty acid profiles improved discrimination of nonfatal MI as compared with established risk factors.
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