Abstract
Synaptic vesicles in rodent neurons are recycled using at least two distinct mechanisms.
Highlights
Related research article Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M. 2016
Stronger stimulation leads to conflicting results: patch clamp studies suggest that a fast mode of endocytosis becomes dominant, whereas fluorescent imaging reports a slowed time course for vesicle recycling
In eLife, Mitsuhara Midorikawa at Doshisha University and co-workers – including Yuji Okamoto as first author – report an elegant series of experiments where they used both patch clamping and fluorescent imaging at the same time to investigate vesicle recycling at a nerve terminal called the calyx of Held in rodents (Okamoto et al, 2016)
Summary
Related research article Okamoto Y, Lipstein N, Hua Y, Lin KH, Brose N, Sakaba T, Midorikawa M. 2016. Doi: 10.7554/ eLife.14643 Image The slower mode of vesicle recycling can take up to tens of seconds, whereas a faster mode takes a few seconds Two techniques have been widely used to study vesicle recycling at synapses: patch clamping and fluorescent imaging.
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