Recyclable palladium-catalyzed Suzuki coupling of aromatic triazine esters: A practical one-pot synthesis of aryl ketones from aromatic acids

Abstract

An efficient heterogeneous palladium-catalyzed Suzuki coupling of aromatic triazine esters with arylboronic acids has been developed. The reaction proceeds smoothly in toluene at 110 °C using 2 mol% of MCM-41-bound bidentate phosphine palladium complex [MCM-41-2P-Pd(OAc)2] as catalyst and provides a novel and practical method for the synthesis of aryl ketones starting from readily available aromatic acids in a one-pot procedure with moderate to excellent yields. The MCM-41-2P-Pd(OAc)2 catalyst can be reused at least seven times without any apparent decrease in its catalytic activity.