Abstract
The mechanical characterization of biological samples is a fundamental issue in biology and related fields, such as tissue and cell mechanics, regenerative medicine and diagnosis of diseases. In this paper, a novel approach for the identification of the stiffness and damping coefficients of biosamples is introduced. According to the proposed method, a MEMS-based microgripper in operational condition is used as a measurement tool. The mechanical model describing the dynamics of the gripper-sample system considers the pseudo-rigid body model for the microgripper, and the Kelvin–Voigt constitutive law of viscoelasticity for the sample. Then, two algorithms based on recursive least square (RLS) methods are implemented for the estimation of the mechanical coefficients, that are the forgetting factor based RLS and the normalised gradient based RLS algorithms. Numerical simulations are performed to verify the effectiveness of the proposed approach. Results confirm the feasibility of the method that enables the ability to perform simultaneously two tasks: sample manipulation and parameters identification.
Highlights
The mechanical characterization of biomaterials represents a crucial procedure in the fields of tissue engineering, tissue and cell mechanics, disease diagnosis and minimally invasive surgery (MIS) [1,2,3]
Microgrippers became essential tools in the manipulation at the microscale [28,29,30,31,32,33], and can be adopted to develop novel techniques for the viscoelastic characterization of soft materials. In their previous investigation [34], the Authors proposed a method to evaluate the mechanical properties of a biomaterial sample based on the use of a MEMS microgripper
To describe the gripper–sample system dynamics, the pseudo-rigid body model and the Kelvin–Voigt constitutive law of viscoelasticity were considered for the microgripper and for the sample, respectively
Summary
The mechanical characterization of biomaterials represents a crucial procedure in the fields of tissue engineering, tissue and cell mechanics, disease diagnosis and minimally invasive surgery (MIS) [1,2,3]. Microgrippers became essential tools in the manipulation at the microscale [28,29,30,31,32,33], and can be adopted to develop novel techniques for the viscoelastic characterization of soft materials In their previous investigation [34], the Authors proposed a method to evaluate the mechanical properties of a biomaterial sample based on the use of a MEMS microgripper. With respect to the other experimental techniques briefly mentioned above, that generally are implemented only for the mechanical testing procedure, the proposed approach enables the ability to perform the mechanical characterization while the sample is manipulated for a different purpose in another operation This method does not require additional elements other than the measurement tool and the specimen as, for example, beads used with optical tweezers.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
