Abstract
BackgroundRetroperitoneal Schwannomas are uncommonly found in the retroperitoneum and few of them show malignant transformation and invasion. Local recurrence are common in malignant Schwannomas with very few reports of tumor distinct differentiation at recurrences.Case presentationWe report here a rare case of retroperitoneal schwannoma with multiple origins from retroperitoneum and pelvic wall. Pathological examination confirmed the case as a schwannoma with malignant transformation. Radical dissection of the tumors along with the sacrifice of adjacent sigmoid colon and left kidney failed to provide a cure for this patient. Due to tumor recurrence, a second and a third surgery of radical excision were performed 6 months and 17 months later after the first surgery, respectively. Histopathologic analysis identified that the recurrent tumors were different from the original schwannoma because of their smooth muscle-like differentiation.ConclusionMalignant schwannomas are uncommon sarcomas with a high incidence of local recurrence. Distinct immunohistochemical staining results of the tumors at recurrence indicate their potential of smooth-muscle like differentiation. Radical excision of the tumors may provide benefit for their local recurrences.
Highlights
Retroperitoneal Schwannomas are uncommonly found in the retroperitoneum and few of them show malignant transformation and invasion
Distinct immunohistochemical staining results of the tumors at recurrence indicate their potential of smooth-muscle like differentiation
Schwannomas are a rare variant of peripheral nerve sheath tumors that seldomly develop to malignancy
Summary
Malignant schwannomas are uncommon sarcomas with a high incidence of local recurrence. Distinct immunohistochemical staining results of the tumors at recurrence indicate their potential of smooth-muscle like differentiation. Radical excision of the tumors may provide benefit for their local recurrences. Pathological findings showed the tumor invasion to the colon seromuscular layer. Pathological findings showed the tumor invasion to renal capsule. Consent Written informed consents were obtained from the patient for publication of this case report and accompanying images. Copies of the written consent are available for review upon request. Competing interests The authors declare that they have no competing interests. Authors’ contributions WHY wrote the initial draft. LZQ and WHY contributed to this work. All authors read and approved the final manuscript.
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