Abstract
The purpose of this study was to explore the factors associated with the recurrence of adenoid cystic carcinomas (ACCs). We examined the recurrence values of clinicopathological variables and GLUT-1, p-Akt and PI3K expression in 42 patients with ACC. Of the 42 patients, 17 developed recurrence following initial surgery. The positive rates of GLUT-1, PI3K and p-Akt protein expression in ACC were 38.1, 38.1 and 50.0%, respectively. The expression of GLUT-1, p-Akt or PI3K protein in ACC was higher than that in inflammatory lesions or benign tumors. Our study demonstrated that T stage, a positive resection margin, perineural invasion, surgery without postoperative radiotherapy and the expression of GLUT-1, PI3K and p-Akt were factors predictive of recurrence by univariate analyses. In multivariate analyses, perineural invasion, a positive resection margin and p-Akt were significant predictors of recurrence. Initial surgery is very significant in the recurrence of ACC. Overexpression of GLUT-1, PI3K and p-Akt may also play a role in its development and recurrence.
Highlights
Adenoid cystic carcinoma (ACC) in the minor salivary glands, including the larynx, nasal cavity, paranasal sinus, external auditory canal and trachea, is uncommon [1,2,3,4]
glucose transporters (GLUTs)-1, phosphatidylinositol 3-kinase (PI3K) and p-Akt immunostaining was evaluated by the same investigator (H.T.Y.), who was blinded to the clinical and follow-up data
PI3K and p-Akt proteins were observed in the nucleus and cytoplasm
Summary
Adenoid cystic carcinoma (ACC) in the minor salivary glands, including the larynx, nasal cavity, paranasal sinus, external auditory canal and trachea, is uncommon [1,2,3,4]. Further studies are needed to identify the pathogenesis, prognostic factors and new diagnostic and therapeutic methods for ACC, at the molecular level
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