Abstract
Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome that is characterized by clinical features including headache, altered mental status, cortical blindness, seizures, and other focal neurological signs as well as subcortical edema without infarction on neuroimaging. Under the umbrella of hypertensive encephalopathy, PRES is defined by reversible cerebral edema due to dysfunction of the cerebrovascular blood-brain barrier unit. The pathophysiology of PRES is thought to result from abnormalities in the transmembrane flow of intravascular fluid and proteins caused by two phenomena: one, cerebral autoregulatory failure and two, loss of integrity of the blood-brain barrier. PRES is not a common disease in patients with human immunodeficiency virus (HIV) and AIDS with only three previously reported cases. Both the HIV and end-stage renal disease appear to further compromise the blood brain barrier. Although uncommon, PRES recurrence has been described. To the best of our knowledge, this is the first report demonstrating recurrent PRES in a HIV patient on hemodialysis for end-stage renal disease.
Highlights
Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiological syndrome that is characterized by clinical features including headache, altered mental status, cortical blindness, seizures, and other focal neurological signs as well as subcortical edema without infarction on neuroimaging
A 28-year-old woman with a history of human immunodeficiency virus (HIV), CD4 count of 28, HIV nephropathy on hemodialysis, and hypertension presented with intractable nausea and vomiting
It is characterized by clinical signs and symptoms of headache, altered mental status, cortical blindness, seizures, and other focal neurological signs [1]
Summary
Recurrent Posterior Reversible Encephalopathy Syndrome Potentially Related to AIDS and End-Stage Renal Disease: A Case Report and Review of the Literature. PRES is not a common disease in patients with human immunodeficiency virus (HIV) and AIDS with only three previously reported cases. Both the HIV and end-stage renal disease appear to further compromise the blood brain barrier. A 28-year-old woman with a history of human immunodeficiency virus (HIV), CD4 count of 28, HIV nephropathy on hemodialysis, and hypertension presented with intractable nausea and vomiting She was known to be poorly compliant with medications. The patient was treated with lorazepam and phenytoin, and her blood pressure was controlled with metoprolol She had no further seizures for the remainder of the hospitalization. The general examination showed the patient was somnolent and partially responsive to verbal and physical stimulation The remainder of her neurologic exam was normal. Follow-up MRI at 2 weeks and 5 months (Figure 1) showed resolution of the edema
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