Recurrent multiple neurofibromatosis type 1 of the right lower limb.

Abstract

Neurofibromatosis type1 is an autosomal dominant inherited disease, which is characterized by the presence of multiple neurofibromas. We encountered acase in which asporadic dispersed neurofibroma recurred locally on numerous occasions extending over 16years. The patient developed multiple masses with afocus of neurofibroma on the right lower limb, which were excised. The patient was initially diagnosed with inflammatory changes via computed tomography and magnetic resonance imaging; however, subsequently, pathological and immunohistochemical examinations revealed an intraneural neurofibroma. The patient underwent acomprehensive and complete local resection several times. After acontinuous postoperative follow-up strategy, the patient recovered well. This report describes acase of primary manifestations of multiple and recurrent neurofibromas. We aim to emphasize the possibility of aunique, recurrent, non-healing neurofibroma and review the diagnostic techniques utilized to reach adefinitive diagnosis. Early and complete surgical resection is an effective method to treat and prevent this type of neurofibroma.