Abstract
Recurrent Monosomies Confirmed by Interphase FISH in Three Chronic Myeloid Leukemia Cases.
Highlights
Chronic myeloid leukemia (CML) is characterized by the Philadelphia (Ph) chromosome, which is the result of t(9;22) (q34;q11) or its variants, 10%-20% of cases have additional cytogenetic abnormalities
fluorescence in situ hybridization (FISH) revealed a hidden monosomy for chromosome 20, but not for chromosome 10
In the first 2 samples of patient 2, monosomy of chromosome 17 was observed in cytogenetic analysis and confirmed by FISH
Summary
Recurrent Monosomies Confirmed by Interphase FISH in Three Chronic Myeloid Leukemia Cases. To the Editor, chronic myeloid leukemia (CML) is characterized by the Philadelphia (Ph) chromosome, which is the result of t(9;22) (q34;q11) or its variants, 10%-20% of cases have additional cytogenetic abnormalities. In the first 3 samples of patient 1, monosomy of chromosomes 8, 10, and 20 was confirmed by FISH. In the fourth sample of this patient, we performed FISH for chromosomes 10 and 20 despite their absence in the karyotype to see whether there was a hidden monosomy that we could not show by karyotyping. In the first 2 samples of patient 2, monosomy of chromosome 17 was observed in cytogenetic analysis and confirmed by FISH. Argüden YT, et al: Recurrent Monosomies Confirmed by Interphase FISH in 3 Chronic Myeloid Leukemia Cases.
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