Abstract
Recurrent Human Rhinovirus Infections in Infants with Refractory Wheezing
Highlights
On the basis of phylogenetic analysis of the VP4 region, we identified 2 patients who had been admitted with 5 episodes of acute respiratory tract infections (RTIs) and subsequent recurrent wheezing associated with Human rhinovirus (HRV)-A and HRV-C
A novel HRV-C infection in association with acute lower RTI was diagnosed in the first patient during her fourth and fifth hospitalizations
Second patient were within the same subgroup, but similarity in nucleotide sequences was only 82.5%. This result suggests that this patient was infected with 2 different virus strains of HRV-A and a strain of HRV-C
Summary
Health workers boycott polio vaccination in Bajaur Agency. Human rhinovirus (HRV) is a cause of acute respiratory tract infections (RTIs) [1]; co-infections with other respiratory viruses such as respiratory syncytial virus (RSV) or influenza virus have been reported. Understanding of the epidemiology of novel HRV infection among Asian pediatric patients with respiratory illness [4,5] and association with recurrent wheezing and asthma has been limited [8,9,10].
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