Recurrent Hodgkin’s Lymphoma with Bleeding: A Case Report

Abstract

Introduction: One of the rare platelet dysfunction, which is impairment of receptor GPIIb/IIIa and platelet aggregation defect, is acquired Glanzmann’s thrombasthenia. A common cause of this thrombasthenia is an autoantibody or plasma protein inhibitor against a normal GPIIb/IIIa glycoprotein. Case Presentation: In this case report, a 28-year-old female with a history of treated Hodgkin’s lymphoma presented with a menometrorrhagia and ecchymosis. Before that, she had no bleeding history and there was no family history bleeding tendency. Laboratory findings revealed bleeding time > 10 minutes, normal partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen, and von Willebrand factor. Platelet-aggregation studies showed no aggregation to adenosine diphosphate (ADP), collagen, and a normal response to ristocetin. The clinical history, medical history, and laboratory findings supported a diagnosis of acquired Glanzmann’s thrombasthenia. Imaging revealed significant lymph nodes was compatible with recurrent disease. The patient’s menorrhagia and bleeding tendency were controlled by systemic chemotherapy. Conclusions: This report shows the association of acquired thrombasthenia with the recurrent Hodgkin’s lymphoma, which can be controlled by remission induction chemotherapy.