Recurrent esophageal candidiasis resistant to fluconazole, complicated by stricture, in a patient with idiopathic immune dysfunction

Abstract

A clinical case of a 62-year-old patient in whom recurrent esophageal candidiasis led to a complication - stricture of the cervical esophagus is presented. The immune dysfunction clarified with the help of an immunological study was characterized by a combined defect in the effectiveness of inflammation, phagocytosis and cytotoxicity, but its cause was not established. In this patient, previous repeated courses of treatment with fluconazole led to the selection of a strain of Candida albicans resistant to fluconazole, therefore, candidiasis was treated with an alternative drug - voriconazole.